天气预报15天查询> 其他> 前药的名词解释

前药的名词解释

更新时间: 2020-09-14 00:00:00     

1、解释,前药又称前体药物、药物前体或前驱药物,是指药物经过化学结构修饰后得到的在体外无活性或活性较小、在体内经酶或非酶的转化释放出活性药物而发挥药效的化合物。

2、概述,1958年,Albert在英国自然杂志上发表文章提出了前体药物的概念。

3、特征,前药应无活性或活性低于原药,原药与载体一般以共价键连接,但到体内可裂变形成原药,此过程可以是简单的酸、碱水解过程或酶促转化过程,前药在体内产生原药的速率应是快速的,以保障原药在靶位有足够的药物浓度,修饰原药的目的是为了延长作用时间时,则可设计代谢速度缓慢的前药。

4、分类,一类是载体前体药物,简称载体前药,另一类是生物前体药物。

关键词: 名词解释

如有意见、反馈、侵权或投诉等情况,请联系:

电话:
邮箱:

我们将会在48小时内给与处理!

版权所有 Copyright ? 2009-2020 tianqiyubao3.com

页面:/news/view-308489/ | 耗时:0.6137 s | 内存:1.89 MB | 查询:4 | 缓存读取:4 写入:0 | 加载文件:23
select * from tbl_Articles WHERE ArticleID=308489 LIMIT 0,1
select * from tbl_Articles_data WHERE ArticleID=308489 LIMIT 0,1
select * from tbl_Articles_sphinx where id=308489 LIMIT 0,1
SELECT ArticleID,Title FROM tbl_Articles WHERE ArticleID IN(4173329,4173328,4173317,4173316,4173154,4173152,4173149,4173148,4173108,4173107,4171466,4171465,4171464,4171463,4171462,4171461,4171460,4171459,4171458,4167535,4167534,4167533,4167532,4167531,4167530,4167529,4165767,4165684,4165652,4165651) ORDER BY field (ArticleID,4173329,4173328,4173317,4173316,4173154,4173152,4173149,4173148,4173108,4173107,4171466,4171465,4171464,4171463,4171462,4171461,4171460,4171459,4171458,4167535,4167534,4167533,4167532,4167531,4167530,4167529,4165767,4165684,4165652,4165651)